BDBM50563465 CHEMBL4758307

SMILES O\N=C\c1cc(Cl)cc(CN2CCN(CC2)c2ccncc2)c1O

InChI Key InChIKey=HSRDSKPYSLWCCY-UHFFFAOYSA-N

Data  1 IC50  4 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50563465   

TargetAcetylcholinesterase(Human)
Fourth Military Medical University

Curated by ChEMBL
LigandPNGBDBM50563465(CHEMBL4758307)
Affinity DataIC50: 2.62E+5nMAssay Description:Inhibition of human AChE assessed as decrease in enzyme activity incubated for 30 mins by Ellman's methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
TargetAcetylcholinesterase(Human)
Fourth Military Medical University

Curated by ChEMBL
LigandPNGBDBM50563465(CHEMBL4758307)
Affinity DataKd:  1.33E+4nMAssay Description:Reactivation of VX-inhibited human AChE assessed as dissociation constant incubated for 30 mins by Ellman's methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
TargetAcetylcholinesterase(Human)
Fourth Military Medical University

Curated by ChEMBL
LigandPNGBDBM50563465(CHEMBL4758307)
Affinity DataKd:  6.70E+3nMAssay Description:Reactivation of sarin-inhibited human AChE assessed as dissociation constant incubated for 30 mins by Ellman's methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
TargetAcetylcholinesterase(Human)
Fourth Military Medical University

Curated by ChEMBL
LigandPNGBDBM50563465(CHEMBL4758307)
Affinity DataKd:  1.06E+3nMAssay Description:Binding affinity to DFP-inhibited human erythrocyte AChE assessed as dissociation constant preincubated with DFP for 15 mins followed by compound and...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetAcetylcholinesterase(Human)
Fourth Military Medical University

Curated by ChEMBL
LigandPNGBDBM50563465(CHEMBL4758307)
Affinity DataKd:  990nMAssay Description:Binding affinity to paraoxon-inhibited human erythrocyte AChE assessed as dissociation constant preincubated with paraoxon for 15 mins followed by co...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed