BDBM50563273 CHEMBL4748500

SMILES ONC(=O)c1ccc(CN2C(=O)c3ccccc3C2=O)cc1-c1ccccc1

InChI Key InChIKey=ONODKKVQHKQFFX-UHFFFAOYSA-N

Data  8 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50563273   

TargetHistone deacetylase 4(Human)
The University of Queensland

Curated by ChEMBL
LigandPNGBDBM50563273(CHEMBL4748500)
Affinity DataIC50: 28nMAssay Description:Inhibition of recombinant human HDAC4 using Ac-LGK(TFA)-AMC as substrate pre-incubated for 15 mins followed by substrate addition and measured after ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
TargetHistone deacetylase 7(Human)
The University of Queensland

Curated by ChEMBL
LigandPNGBDBM50563273(CHEMBL4748500)
Affinity DataIC50: 12nMAssay Description:Inhibition of recombinant human HDAC7 using Ac-LGK(TFA)-AMC as substrate pre-incubated for 15 mins followed by substrate addition and measured after ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
TargetHistone deacetylase 1(Human)
The University of Queensland

Curated by ChEMBL
LigandPNGBDBM50563273(CHEMBL4748500)
Affinity DataIC50: 3.20E+4nMAssay Description:Inhibition of recombinant human HDAC1 using Ac-LGK(Ac)-AMC as substrate preincubated for 30 mins followed by substrate addition and measured after 90...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
TargetHistone deacetylase 5(Human)
The University of Queensland

Curated by ChEMBL
LigandPNGBDBM50563273(CHEMBL4748500)
Affinity DataIC50: 12nMAssay Description:Inhibition of recombinant human HDAC5 using Ac-LGK(TFA)-AMC as substrate pre-incubated for 15 mins followed by substrate addition and measured after ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
TargetHistone deacetylase 6(Human)
The University of Queensland

Curated by ChEMBL
LigandPNGBDBM50563273(CHEMBL4748500)
Affinity DataIC50: 6.40E+3nMAssay Description:Inhibition of recombinant human HDAC6 using Boc-Lys(Ac)-AMC as substrate pre-incubated for 15 mins followed by substrate addition and measured after ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
TargetHistone deacetylase 8(Human)
The University of Queensland

Curated by ChEMBL
LigandPNGBDBM50563273(CHEMBL4748500)
Affinity DataIC50: 72nMAssay Description:Inhibition of recombinant human HDAC8 using Ac-LGK(TFA)-AMC as substrate preincubated for 30 mins followed by substrate addition and measured after 9...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
TargetHistone deacetylase 9(Human)
The University of Queensland

Curated by ChEMBL
LigandPNGBDBM50563273(CHEMBL4748500)
Affinity DataIC50: 20nMAssay Description:Inhibition of recombinant human HDAC9 using Ac-LGK(TFA)-AMC as substrate preincubated for 15 mins followed by substrate addition and measured after 6...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
TargetHistone deacetylase 1/2/3/8(Human)
The University of Queensland

Curated by ChEMBL
LigandPNGBDBM50563273(CHEMBL4748500)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of Class 1 histone deacetylase in human THP-1 cells using Ac-LGK(Ac)-AMC as substrate incubated for 3 hrs followed by 50 uM SAHA addition ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed