BDBM50562612 CHEMBL4749741

SMILES Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)CCCNC(=O)c2ccc(cc2)-c2cnc(NCc3ccco3)n3cnnc23)C(C)(C)C)cc1

InChI Key InChIKey=PPNNFXIBKLCMTI-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50562612   

TargetPolycomb protein EED(Human)
Northwestern University

Curated by ChEMBL
LigandPNGBDBM50562612(CHEMBL4749741)
Affinity DataIC50: 247nMAssay Description:Displacement of UNC5114-biotin tracer ligand from N-terminal 6His-tagged EED (1 to 441 residues) (unknown origin) expressed in Escherichia coli Roset...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
TargetHistone-lysine N-methyltransferase EZH2(Human)
Sanquan College of Xinxiang Medical University

Curated by ChEMBL
LigandPNGBDBM50562612(CHEMBL4749741)
Affinity DataIC50: 300nMAssay Description:Inhibition of EZH2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetPolycomb protein EED(Human)
Northwestern University

Curated by ChEMBL
LigandPNGBDBM50562612(CHEMBL4749741)
Affinity DataIC50: 247nMAssay Description:Inhibition of full length N-terminal His-6x tagged EED (1 to 441 residues) (unknown origin) incubated for 1 hr by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetPolycomb protein EED(Human)
Northwestern University

Curated by ChEMBL
LigandPNGBDBM50562612(CHEMBL4749741)
Affinity DataIC50: 247nMAssay Description:Inhibition of PRC2 catalytic core EED (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed