BDBM50562609 CHEMBL4787413

SMILES CC(C)n1ncc2c(cc(cc12)-c1ccc(nc1)N1CCN(CCNC(=O)CC23CC4CC(CC(C4)C2)C3)CC1)C(=O)NCc1c(C)cc(C)[nH]c1=O

InChI Key

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50562609   

TargetHistone-lysine N-methyltransferase EZH2(Human)
Northwestern University

Curated by ChEMBL
LigandPNGBDBM50562609(CHEMBL4787413)
Affinity DataIC50: 120nMAssay Description:Inhibition of EZH2 in PRC2 complex (unknown origin) using core histone as substrate in presence of SAMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
TargetHistone-lysine N-methyltransferase EZH2(Human)
Northwestern University

Curated by ChEMBL
LigandPNGBDBM50562609(CHEMBL4787413)
Affinity DataIC50: 120nMAssay Description:Inhibition of EZH2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/19/2023
Entry Details
PubMed
TargetHistone-lysine N-methyltransferase EZH2(Human)
Northwestern University

Curated by ChEMBL
LigandPNGBDBM50562609(CHEMBL4787413)
Affinity DataIC50: 120nMAssay Description:Inhibition of human EZH2 using core histone as substrate in presence of SAMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetHistone-lysine N-methyltransferase EZH2(Human)
Northwestern University

Curated by ChEMBL
LigandPNGBDBM50562609(CHEMBL4787413)
Affinity DataIC50: 120nMAssay Description:Inhibition of EZH2 methyltransferase activity (unknown origin) assessed `transfer of [3H]methyl group from SAM to substrate by biochemical assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed