BDBM50562605 CHEMBL4545488

SMILES CCCc1cc(C)[nH]c(=O)c1CNC(=O)c1cc(nc2n(ncc12)C(C)C)-c1ccc(nc1)N1CCN(C)CC1

InChI Key InChIKey=LQTWDAYNGMMHLV-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50562605   

TargetHistone-lysine N-methyltransferase EZH2(Human)
Northwestern University

Curated by ChEMBL
LigandPNGBDBM50562605(CHEMBL4545488)
Affinity DataIC50: 11nMAssay Description:Inhibition of EZH2 in PRC2 complex (unknown origin) expressed in Sf9 cells using histone H3 (21 to 44)-lys (biotin) and SAM as substrate incubated fo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
TargetHistone-lysine N-methyltransferase EZH2(Human)
Northwestern University

Curated by ChEMBL
LigandPNGBDBM50562605(CHEMBL4545488)
Affinity DataIC50: 11nMAssay Description:Inhibition of EZH2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/19/2023
Entry Details
PubMed
TargetHistone-lysine N-methyltransferase EZH2(Human)
Northwestern University

Curated by ChEMBL
LigandPNGBDBM50562605(CHEMBL4545488)
Affinity DataIC50: 80nMAssay Description:Inhibition of N-terminal FLAG-tagged recombinant full-length human EZH2 Y641F mutant in PRC2 complex expressed in baculovirus infected Sf9 cells usin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed