BDBM50562468 CHEMBL4743740

SMILES Cc1ccc(-c2cn(CCN3CCOCC3)nn2)c(NC(=O)c2cc(=O)c3ccccc3o2)c1

InChI Key InChIKey=QDMNYDIHPHLOQL-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50562468   

TargetBroad substrate specificity ATP-binding cassette transporter ABCG2(Human)
University of Regensburg

Curated by ChEMBL
LigandPNGBDBM50562468(CHEMBL4743740)
Affinity DataIC50: 188nMAssay Description:Inhibition of human ABCG2 in human MCF7/Topo cells assessed as accumulation of substrate Hoechst 33345 stain measured after 2 hrs by fluorometric mic...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
TargetATP-dependent translocase ABCB1(Human)
University of Regensburg

Curated by ChEMBL
LigandPNGBDBM50562468(CHEMBL4743740)
Affinity DataIC50: 1.60E+3nMAssay Description:Inhibition of ABCB1 in human KB-V1 cells assessed as accumulation of substrate calcein-AM stain measured after 10 mins by fluorometric microplate rea...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed