BDBM50562032 CHEMBL4789409

SMILES Cc1nnc(o1)-c1ccc(Nc2nc3N(CCCn3n2)c2cccc(Cl)c2)cc1

InChI Key InChIKey=BFAHJNDZUPNGPN-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50562032   

TargetPresenilin-1(Human)
Roche Innovation Center Basel

Curated by ChEMBL
LigandPNGBDBM50562032(CHEMBL4789409)
Affinity DataIC50: 95nMAssay Description:Modulatory activity of gamma secretase in human H4 cells overexpressing human APP695 K595N/M596L mutant assessed as decrease in amyloidbeta42 levels ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed