BDBM50561927 CHEMBL4740783::US11236069, Example 11-62

SMILES Cc1cc(NC(=O)c2ccc(NS(=O)(=O)CCO)cc2N2CCC3(CC3)CC2)nc(NC(C)(C)CO)n1

InChI Key InChIKey=IMTVFWPLCAYRGU-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50561927   

TargetKinesin-like protein KIF18A(Human)
Smith, Gambrell & Russell

Curated by ChEMBL
LigandPNGBDBM50561927(US11236069, Example 11-62 | CHEMBL4740783)
Affinity DataIC50: 18nMAssay Description:Inhibition of recombinant human His-tagged KIF18A (1 to 467 residues) expressed in baculovirus expression system assessed as inhibition of microtubul...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetKinesin-like protein KIF18A [1-467](Human)
Amgen

US Patent
LigandPNGBDBM50561927(US11236069, Example 11-62 | CHEMBL4740783)
Affinity DataIC50: 18nMAssay Description:Microtubule-stimulated ATPase activity assay is used to measure KIF18A enzyme activity after treatment with compound. Compounds were 2-fold serially ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/6/2022
Entry Details
Go to US Patent