BDBM50561926 CHEMBL4776120::US11236069, Example 11-25

SMILES Cc1cc(NC(=O)c2ccc(NS(=O)(=O)CCO)cc2N2CCC3(CC3)CC2)nc(n1)N1CCC2(CC2)C1

InChI Key InChIKey=CYHXCLUPJDLMGG-UHFFFAOYSA-N

Data  2 IC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50561926   

TargetKinesin-like protein KIF18A(Human)
Smith, Gambrell & Russell

Curated by ChEMBL

LigandBDBM50561926(US11236069, Example 11-25 | CHEMBL4776120)Copy SMILESCopy InChI

Affinity DataIC50: 18nMAssay Description:Inhibition of recombinant human His-tagged KIF18A (1 to 467 residues) expressed in baculovirus expression system assessed as inhibition of microtubul...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
3/28/2022
Entry Details Article
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TargetKinesin-like protein KIF18A [1-467](Human)
Amgen

US Patent

LigandBDBM50561926(US11236069, Example 11-25 | CHEMBL4776120)Copy SMILESCopy InChI

Affinity DataIC50: 17.6nMAssay Description:Microtubule-stimulated ATPase activity assay is used to measure KIF18A enzyme activity after treatment with compound. Compounds were 2-fold serially ...More data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
6/6/2022
Entry Details
Copy Entry DOIGo to US Patent

Copy Rxn URL