BDBM50561923 CHEMBL4751673::US11236069, Example 6-24-1

SMILES C[C@@H](CO)S(=O)(=O)Nc1ccc(C(=O)Nc2ccnc(n2)N2CCO[C@H](C)C2)c(c1)N1CCC2(CC2)CC1

InChI Key InChIKey=IAHRXNBHVAZFBW-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50561923   

TargetKinesin-like protein KIF18A(Human)
Smith, Gambrell & Russell

Curated by ChEMBL
LigandPNGBDBM50561923(US11236069, Example 6-24-1 | CHEMBL4751673)
Affinity DataIC50: 17nMAssay Description:Inhibition of recombinant human His-tagged KIF18A (1 to 467 residues) expressed in baculovirus expression system assessed as inhibition of microtubul...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetKinesin-like protein KIF18A [1-467](Human)
Amgen

US Patent
LigandPNGBDBM50561923(US11236069, Example 6-24-1 | CHEMBL4751673)
Affinity DataIC50: 17.4nMAssay Description:Microtubule-stimulated ATPase activity assay is used to measure KIF18A enzyme activity after treatment with compound. Compounds were 2-fold serially ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/6/2022
Entry Details
Go to US Patent