BDBM50561898 CHEMBL4790744

SMILES CN1CC2(CCN(CC2)Cc3ccc(cc3)C(=O)NO)c4c1cccc4

InChI Key InChIKey=KRAFQDJIYXJLQM-UHFFFAOYSA-N

Data  3 IC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50561898   

TargetHistone deacetylase 1(Human)
University of Siena

Curated by ChEMBL
LigandPNGBDBM50561898(CHEMBL4790744)
Affinity DataIC50: 2.24E+4nMAssay Description:Inhibition of full length C-terminal His/FLAG-tagged human HDAC1 expressed in baculovirus expression system using ZMAL as substrate incubated for 90 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetHistone deacetylase 6(Human)
University of Siena

Curated by ChEMBL
LigandPNGBDBM50561898(CHEMBL4790744)
Affinity DataIC50: 264nMAssay Description:Inhibition of full length N-terminal GST-tagged human HDAC6 expressed in baculovirus expression system using ZMAL as substrate incubated for 90 mins ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetHistone deacetylase 8(Human)
University of Siena

Curated by ChEMBL
LigandPNGBDBM50561898(CHEMBL4790744)
Affinity DataIC50: 1.91E+3nMAssay Description:Inhibition of human recombinant HDAC8 expressed in Escherichia coli using Fluor de Lys substrate preincubated for 15 mins followed by substrate addit...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed