BDBM50561818 CHEMBL4783377

SMILES CN1CCC2(CCCN2C[C@H]2O[C@H]([C@H](O)[C@@H]2O)n2ccc3c(N)ncnc23)CC1

InChI Key InChIKey=UJBWICUCTXANPU-UHFFFAOYSA-N

Data  2 IC50  1 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50561818   

TargetMethylosome protein 50/Protein arginine N-methyltransferase 5(Human)
Janssen Pharmaceutica

Curated by ChEMBL
LigandPNGBDBM50561818(CHEMBL4783377)
Affinity DataIC50: 48nMAssay Description:Inhibition of full-length human N-terminal FLAG-tagged PRMT5/full length N-terminal His6-tagged MEP50 (unknown origin) expressed in baculovirus infec...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetProtein arginine N-methyltransferase 5(Human)
Janssen Pharmaceutica

Curated by ChEMBL
LigandPNGBDBM50561818(CHEMBL4783377)
Affinity DataIC50: 200nMAssay Description:Inhibition of PRMT5 in human A549 cells assessed as reduction in arginine dimethylation of SmD1/3 after 48 hrs by Hoechst Stain/ CellMask Deep Red St...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetMethylosome protein 50/Protein arginine N-methyltransferase 5(Human)
Janssen Pharmaceutica

Curated by ChEMBL
LigandPNGBDBM50561818(CHEMBL4783377)
Affinity DataKd:  7.60nMAssay Description:Binding affinity to N-terminal FLAG-tagged human PRMT5 (1 to 637 residues)/N-terminal thrombin His-tagged MEP50 (2 to 342 residues) expressed in bacu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed