BDBM50561816 CHEMBL4758857

SMILES NCC[C@@H]1CCCN1C[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1cnc2c(N)ncnc12

InChI Key InChIKey=VXDZQEMICWJXQW-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50561816   

TargetMethylosome protein 50/Protein arginine N-methyltransferase 5(Human)
Janssen Pharmaceutica

Curated by ChEMBL
LigandPNGBDBM50561816(CHEMBL4758857)
Affinity DataIC50: 83nMAssay Description:Inhibition of full-length human N-terminal FLAG-tagged PRMT5/full length N-terminal His6-tagged MEP50 (unknown origin) expressed in baculovirus infec...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetProtein arginine N-methyltransferase 5(Human)
Janssen Pharmaceutica

Curated by ChEMBL
LigandPNGBDBM50561816(CHEMBL4758857)
Affinity DataIC50: 2.40E+3nMAssay Description:Inhibition of PRMT5 in human A549 cells assessed as reduction in arginine dimethylation of SmD1/3 after 48 hrs by Hoechst Stain/ CellMask Deep Red St...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed