BDBM50561276 CHEMBL4740234

SMILES CC(=O)N1CCN(CC1)c1ccc(Nc2ncc(Cl)c(Nc3cccc(NC(=O)C(Cl)=C)c3)n2)cn1

InChI Key InChIKey=DZQBJHDPYKJSHR-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50561276   

TargetEpidermal growth factor receptor(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50561276(CHEMBL4740234)
Affinity DataIC50: 130nMAssay Description:Inhibition of wild type EGFR (unknown origin) in presence of ATP preincubated 5 mins measured for 30 mins by detection reagent based HTRF analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50561276(CHEMBL4740234)
Affinity DataIC50: 7.5nMAssay Description:Inhibition of recombinant human EGFR T790M/L858R mutant expressed in baculovirus insect cell expression system in presence of ATP preincubated 5 mins...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed