BDBM50561273 CHEMBL4746377

SMILES COc1cc(ccc1Nc1ncc(c(Nc2cccc(NC(=O)C(Cl)=C)c2)n1)C(F)(F)F)N1CCN(CC1)C(C)=O

InChI Key InChIKey=SCTASBKVPAEZPZ-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50561273   

TargetEpidermal growth factor receptor(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50561273(CHEMBL4746377)
Affinity DataIC50: 257nMAssay Description:Inhibition of wild type EGFR (unknown origin) in presence of ATP preincubated 5 mins measured for 30 mins by detection reagent based HTRF analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50561273(CHEMBL4746377)
Affinity DataIC50: 16nMAssay Description:Inhibition of recombinant human EGFR T790M/L858R mutant expressed in baculovirus insect cell expression system in presence of ATP preincubated 5 mins...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed