BDBM50561206 CHEMBL4764985

SMILES COC[C@](CO)(OC[C@@H]1[C@H]([C@H]([C@@H](O1)n2c3c(cn2)c(nc(n3)Cl)NC4CCCC4)O)O)P(=O)(O)O

InChI Key InChIKey=BQCRMLSBGAKPFW-UHFFFAOYSA-N

Data  5 IC50  3 EC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50561206   

Target5'-nucleotidase(Human)
Oric Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50561206(CHEMBL4764985)
Affinity DataEC50:  0.220nMAssay Description:Inhibition of CD73 in human CD8+ T-cells assessed as reduction in AMP-induced ADO expression preincubated for 15 mins followed by AMP addition and me...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMedPDB3D3D Structure (crystal)
Target5'-nucleotidase(Human)
Oric Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50561206(CHEMBL4764985)
Affinity DataIC50: 0.25nMAssay Description:Inhibition of human C-terminal His6-tagged CD73 expressed in CHO cells preincubated for 15 mins followed by AMP addition and measured after 10 mins b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMedPDB3D3D Structure (crystal)
Target5'-nucleotidase(Human)
Oric Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50561206(CHEMBL4764985)
Affinity DataEC50:  0.790nMAssay Description:Inhibition of CD73 in human NCI-H1568 cells assessed as reduction in AMP-induced ADO expression preincubated for 15 mins followed by AMP addition and...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMedPDB3D3D Structure (crystal)
Target5'-nucleotidase(Mouse)
Oric Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50561206(CHEMBL4764985)
Affinity DataEC50:  14nMAssay Description:Inhibition of CD73 in mouse EMT6 cells assessed as reduction in AMP-induced ADO expression preincubated for 15 mins followed by AMP addition and meas...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetCytochrome P450 3A4(Human)
Oric Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50561206(CHEMBL4764985)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of CYP3A4 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetCytochrome P450 2C8(Human)
Oric Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50561206(CHEMBL4764985)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of CYP2C8 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetCytochrome P450 2C9(Human)
Oric Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50561206(CHEMBL4764985)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of CYP2C9 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
Target5'-nucleotidase(Human)
Oric Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50561206(CHEMBL4764985)
Affinity DataIC50: 250nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMedPDB3D3D Structure (crystal)