BDBM50560359 CHEMBL4762866

SMILES Cc1cc(-c2cnc(OCC34CCC(N)(CC3)CC4)c(C)c2)c2cnn(C)c2n1

InChI Key InChIKey=SUPJVKWVZUUSFT-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50560359   

TargetToll-like receptor 7(Human)
Genomics Institute of The Novartis Research Foundation

Curated by ChEMBL
LigandPNGBDBM50560359(CHEMBL4762866)
Affinity DataIC50: 1nMAssay Description:Antagonist activity at TLR7 in human PBMC assessed as inhibition of ssRNA40-induced IFNalpha productionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetToll-like receptor 8(Human)
Genomics Institute of The Novartis Research Foundation

Curated by ChEMBL
LigandPNGBDBM50560359(CHEMBL4762866)
Affinity DataIC50: 2nMAssay Description:Antagonist activity at TLR8 in human THP-1 cells assessed as inhibition of resiquimod-induced TNFalpha productionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetToll-like receptor 7(Human)
Genomics Institute of The Novartis Research Foundation

Curated by ChEMBL
LigandPNGBDBM50560359(CHEMBL4762866)
Affinity DataIC50: 1nMAssay Description:Antagonist activity at TLR7 in human PBMC cells assessed as reduction in IFN alpha measured after 20 hrs by AlphaLISA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetToll-like receptor 7(Mouse)
Novartis Institutes for Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50560359(CHEMBL4762866)
Affinity DataIC50: 5nMAssay Description:Antagonist activity at TLR7 in mouse Splenocyte assessed as reduction in IFN-alpha level measured after 20 hrs by Spectramax M5 methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed