BDBM50560346 CHEMBL4743698

SMILES CN1CCN(CCCOc2ccc(cc2F)-c2nn(C)c3nc(N)ncc23)CC1

InChI Key InChIKey=JOFZICSYCUPGPF-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50560346   

TargetToll-like receptor 7(Mouse)
Genomics Institute of The Novartis Research Foundation

Curated by ChEMBL
LigandPNGBDBM50560346(CHEMBL4743698)
Affinity DataIC50: 170nMAssay Description:Antagonist activity at TLR7 in mouse P4H1 cells assessed as inhibition of imiquimod-induced IL6 productionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetToll-like receptor 7(Mouse)
Genomics Institute of The Novartis Research Foundation

Curated by ChEMBL
LigandPNGBDBM50560346(CHEMBL4743698)
Affinity DataIC50: 2.00E+3nMAssay Description:Antagonist activity at TLR7 in mouse splenocytes assessed as inhibition of ssRNA40-induced IL6 productionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetToll-like receptor 9(Mouse)
Genomics Institute of The Novartis Research Foundation

Curated by ChEMBL
LigandPNGBDBM50560346(CHEMBL4743698)
Affinity DataIC50: 2.00E+3nMAssay Description:Antagonist activity at TLR9 in mouse splenocytes assessed as inhibition of CpG1585-induced IL6 productionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetToll-like receptor 7(Human)
Genomics Institute of The Novartis Research Foundation

Curated by ChEMBL
LigandPNGBDBM50560346(CHEMBL4743698)
Affinity DataIC50: 310nMAssay Description:Antagonist activity at TLR7 in human PBMC assessed as inhibition of ssRNA40-induced IFNalpha productionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed