BDBM50559904 CHEMBL4788256

SMILES [H][C@@]12C[C@]1(COC)SC(N)=N[C@]2(CF)c1cc(\C=C\c2ccc(Cl)cn2)ccc1F

InChI Key InChIKey=OQLQVZYNLHFGOD-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50559904   

TargetBeta-secretase 1(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50559904(CHEMBL4788256)
Affinity DataIC50: 940nMAssay Description:Inhibition of recombinant human BACE1 using fluorescence substrate preincubated for 60 mins followed by substrate addition and measured after 60 mins...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetBeta-secretase 2(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50559904(CHEMBL4788256)
Affinity DataIC50: 1.37E+3nMAssay Description:Inhibition of recombinant human BACE2 using fluorescence substrate preincubated for 60 mins followed by substrate addition and measured after 60 mins...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50559904(CHEMBL4788256)
Affinity DataIC50: 2.20E+3nMAssay Description:Inhibition of BACE1 in human HEK293 cells transfected with human wild type APP assessed as reduction in Abeta40 production incubated for overnight by...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed