BDBM50559798 CHEMBL4758063::US11370770, Compound 6ff

SMILES OC(=O)c1ccc(cc1)-c1n[nH]c2cc(F)ccc12

InChI Key InChIKey=JCIIJLGOZRZKPD-UHFFFAOYSA-N

Data  10 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 50559798   

TargetDual specificity mitogen-activated protein kinase kinase 4(Human)
Northwestern University

Curated by ChEMBL
LigandPNGBDBM50559798(CHEMBL4758063 | US11370770, Compound 6ff)
Affinity DataIC50: 41nMAssay Description:Inhibition of MEK4 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetDual specificity mitogen-activated protein kinase kinase 4(Human)
Northwestern University

Curated by ChEMBL
LigandPNGBDBM50559798(CHEMBL4758063 | US11370770, Compound 6ff)
Affinity DataIC50: 41nMAssay Description:Kinase activity of recombinant active full-length human MEK4 (Carna Biosciences) was measured using the ADP-Glo assay (Promega) with 3 μM recomb...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/25/2022
Entry Details
Go to US Patent

TargetDual specificity mitogen-activated protein kinase kinase 4(Human)
Northwestern University

Curated by ChEMBL
LigandPNGBDBM50559798(CHEMBL4758063 | US11370770, Compound 6ff)
Affinity DataIC50: 66nMAssay Description:Kinase activity of recombinant active full-length human MEK4 (Carna Biosciences) was measured using the ADP-Glo assay (Promega) with 3 μM recomb...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/25/2022
Entry Details
Go to US Patent

TargetDual specificity mitogen-activated protein kinase kinase 4(Human)
Northwestern University

Curated by ChEMBL
LigandPNGBDBM50559798(CHEMBL4758063 | US11370770, Compound 6ff)
Affinity DataIC50: 100nMAssay Description:Kinase activity of recombinant active full-length human MEK4 (Carna Biosciences) was measured using the ADP-Glo assay (Promega) with 3 μM recomb...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/25/2022
Entry Details
Go to US Patent

TargetMitogen-activated protein kinase 1(Human)
Northwestern University

US Patent
LigandPNGBDBM50559798(CHEMBL4758063 | US11370770, Compound 6ff)
Affinity DataIC50: 1.50E+4nMAssay Description:Kinase activity of recombinant active full-length human MEK4 (Carna Biosciences) was measured using the ADP-Glo assay (Promega) with 3 μM recomb...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/25/2022
Entry Details
Go to US Patent

TargetMAP kinase-activated protein kinase 2(Human)
Northwestern University

US Patent
LigandPNGBDBM50559798(CHEMBL4758063 | US11370770, Compound 6ff)
Affinity DataIC50: 2.70E+4nMAssay Description:Kinase activity of recombinant active full-length human MEK4 (Carna Biosciences) was measured using the ADP-Glo assay (Promega) with 3 μM recomb...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/25/2022
Entry Details
Go to US Patent

TargetMAP kinase-activated protein kinase 3(Human)
Northwestern University

US Patent
LigandPNGBDBM50559798(CHEMBL4758063 | US11370770, Compound 6ff)
Affinity DataIC50: 2.70E+4nMAssay Description:Kinase activity of recombinant active full-length human MEK4 (Carna Biosciences) was measured using the ADP-Glo assay (Promega) with 3 μM recomb...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/25/2022
Entry Details
Go to US Patent

TargetMAP kinase-activated protein kinase 5(Human)
Northwestern University

US Patent
LigandPNGBDBM50559798(CHEMBL4758063 | US11370770, Compound 6ff)
Affinity DataIC50: 2.70E+4nMAssay Description:Kinase activity of recombinant active full-length human MEK4 (Carna Biosciences) was measured using the ADP-Glo assay (Promega) with 3 μM recomb...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/25/2022
Entry Details
Go to US Patent

TargetMitogen-activated protein kinase 6(Human)
Northwestern University

US Patent
LigandPNGBDBM50559798(CHEMBL4758063 | US11370770, Compound 6ff)
Affinity DataIC50: 1.10E+4nMAssay Description:Kinase activity of recombinant active full-length human MEK4 (Carna Biosciences) was measured using the ADP-Glo assay (Promega) with 3 μM recomb...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/25/2022
Entry Details
Go to US Patent

TargetMitogen-activated protein kinase 7(Human)
Northwestern University

US Patent
LigandPNGBDBM50559798(CHEMBL4758063 | US11370770, Compound 6ff)
Affinity DataIC50: 1.20E+4nMAssay Description:Kinase activity of recombinant active full-length human MEK4 (Carna Biosciences) was measured using the ADP-Glo assay (Promega) with 3 μM recomb...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/25/2022
Entry Details
Go to US Patent