BDBM50559547 CHEMBL4754303

SMILES FC(F)COc1ccc2nn(-c3ccc4ncsc4c3)c(=O)c(-c3ccc(OC(F)F)cc3)c2n1

InChI Key InChIKey=CQIGXCZYULOKHV-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50559547   

TargetS-adenosylmethionine synthase isoform type-2(Human)
Usona Institute

Curated by ChEMBL
LigandPNGBDBM50559547(CHEMBL4754303)
Affinity DataIC50: 100nMAssay Description:Inhibition of recombinant human MAT2A expressed in baculovirus infected Sf9 cells using L-methionine as substrate incubated for 60 mins followed by s...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetS-adenosylmethionine synthase isoform type-2(Human)
Usona Institute

Curated by ChEMBL
LigandPNGBDBM50559547(CHEMBL4754303)
Affinity DataIC50: 100nMAssay Description:Inhibition of MAT2A in human HCT-116 cells assessed as reduction in SAM incubated for 72 hrs by LC-MS/MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed