BDBM50559476 CHEMBL4796417

SMILES CN1c2cnc(N[C@H]3CC[C@H](O)CC3)cc2Oc2ccccc2C1=O

InChI Key InChIKey=YOSFKTZILAAWFE-UHFFFAOYSA-N

Data  3 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50559476   

TargetBromodomain-containing protein 4(Human)
Kyorin Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50559476(CHEMBL4796417)
Affinity DataEC50:  2.70E+3nMAssay Description:Inhibition of BRD4 in human PBMC assessed as reduction in LPS-induced TNFalpha secretion preincubated for 1 hr followed by LPS-stimulation and measur...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 7(Human)
Kyorin Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50559476(CHEMBL4796417)
Affinity DataIC50: 266nMAssay Description:Inhibition of recombinant human ERK5 using myelin basic protein as substrate by [gamm33P]ATP based HotSpot radiometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Kyorin Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50559476(CHEMBL4796417)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human ERG stably expressed in CHO cells at holding potential of -80 mV incubated for 12 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetBromodomain-containing protein 4(Human)
Kyorin Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50559476(CHEMBL4796417)
Affinity DataIC50: 9.37E+3nMAssay Description:Inhibition of BRD4-BD1 (unknown origin) by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed