BDBM50559472 CHEMBL4758899

SMILES COc1cccc2c1Oc1cc(N[C@H]3CC[C@H](O)CC3)ncc1N(C)C2=O

InChI Key InChIKey=ZMHYPFNJWLHCSC-UHFFFAOYSA-N

Data  3 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50559472   

TargetBromodomain-containing protein 4(Human)
Kyorin Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50559472(CHEMBL4758899)
Affinity DataEC50:  1.38E+3nMAssay Description:Inhibition of BRD4 in human PBMC assessed as reduction in LPS-induced TNFalpha secretion preincubated for 1 hr followed by LPS-stimulation and measur...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 7(Human)
Kyorin Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50559472(CHEMBL4758899)
Affinity DataIC50: 1.10E+3nMAssay Description:Inhibition of recombinant human ERK5 using myelin basic protein as substrate by [gamm33P]ATP based HotSpot radiometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Kyorin Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50559472(CHEMBL4758899)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human ERG stably expressed in CHO cells at holding potential of -80 mV incubated for 12 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetBromodomain-containing protein 4(Human)
Kyorin Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50559472(CHEMBL4758899)
Affinity DataIC50: 2.82E+3nMAssay Description:Inhibition of BRD4-BD1 (unknown origin) by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed