BDBM50559289 CHEMBL4789556

SMILES CCN(CC)C(=O)\C=C\CN1CCc2cc(Nc3ncc(C)c(n3)-c3cnn(c3)C(C)C)ccc2C1

InChI Key InChIKey=LEJYYBYZPRLYLD-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50559289   

TargetTyrosine-protein kinase JAK2(Human)
West China Hospital of Sichuan University

Curated by ChEMBL
LigandPNGBDBM50559289(CHEMBL4789556)
Affinity DataIC50: 329nMAssay Description:Inhibition of JAK2 V617F mutant in human SET-2 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK2(Mouse)
West China Hospital of Sichuan University

Curated by ChEMBL
LigandPNGBDBM50559289(CHEMBL4789556)
Affinity DataIC50: 287nMAssay Description:Inhibition of JAK2 V617F mutant in mouse BaF3 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details Article
PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
West China Hospital of Sichuan University

Curated by ChEMBL
LigandPNGBDBM50559289(CHEMBL4789556)
Affinity DataIC50: 656nMAssay Description:Inhibition of FLT3 ITD mutant in human MOLM13 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details Article
PubMed