BDBM50559284 CHEMBL4753549

SMILES CC(C)n1cc(cn1)-c1nc(Nc2ccc3CN(CCc3c2)C(=O)\C=C\CN(C)C)ncc1C

InChI Key InChIKey=SURRDPSGERGIIM-UHFFFAOYSA-N

Data  15 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 15 hits for monomerid = 50559284   

TargetTyrosine-protein kinase JAK2(Human)
West China Hospital of Sichuan University

Curated by ChEMBL
LigandPNGBDBM50559284(CHEMBL4753549)
Affinity DataIC50: 12nMAssay Description:Inhibition of JAK2 V617F mutant in human SET-2 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK2(Mouse)
West China Hospital of Sichuan University

Curated by ChEMBL
LigandPNGBDBM50559284(CHEMBL4753549)
Affinity DataIC50: 41nMAssay Description:Inhibition of JAK2 V617F mutant in mouse BaF3 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details Article
PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
West China Hospital of Sichuan University

Curated by ChEMBL
LigandPNGBDBM50559284(CHEMBL4753549)
Affinity DataIC50: 880nMAssay Description:Inhibition of FLT3 ITD mutant in human MOLM13 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK1(Human)
West China Hospital of Sichuan University

Curated by ChEMBL
LigandPNGBDBM50559284(CHEMBL4753549)
Affinity DataIC50: 42nMAssay Description:Inhibition of human JAK1 (866 to end residues) using GEEPLYWSFPAKKK as substrate after 40 mins by [gamma-33ATP] radiometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK2(Human)
West China Hospital of Sichuan University

Curated by ChEMBL
LigandPNGBDBM50559284(CHEMBL4753549)
Affinity DataIC50: 3nMAssay Description:Inhibition of recombinant human JAK2 (808 to end residues) KTFCGTPEYLAPEVRREPRILSEEEQEMFRDFDYIADWC as substrate measured after 40 mins in presence of...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK3(Human)
West China Hospital of Sichuan University

Curated by ChEMBL
LigandPNGBDBM50559284(CHEMBL4753549)
Affinity DataIC50: 94nMAssay Description:Inhibition of recombinant human JAK3 (781 to end residues) using GGEEEEYFELVKKKK as substrate measured after 40 mins in presence of [gamm33P]ATP by s...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details Article
PubMed
TargetNon-receptor tyrosine-protein kinase TYK2(Human)
West China Hospital of Sichuan University

Curated by ChEMBL
LigandPNGBDBM50559284(CHEMBL4753549)
Affinity DataIC50: 75nMAssay Description:Inhibition of recombinant human TYK2 (875 to end residues) using GGMEDIYFEFMGGKKK as substrate incubated for 40 mins in presence of [gamma33P]ATP by ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details Article
PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
West China Hospital of Sichuan University

Curated by ChEMBL
LigandPNGBDBM50559284(CHEMBL4753549)
Affinity DataIC50: 62nMAssay Description:Inhibition of recombinant human FLT3 D835Y mutant (564 to end residues) using EAIYAAPFAKKK as substrate at 40 mins in presence of [gamma-33ATP] by sc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK2(Human)
West China Hospital of Sichuan University

Curated by ChEMBL
LigandPNGBDBM50559284(CHEMBL4753549)
Affinity DataIC50: 475nMAssay Description:Inhibition of JAK2 V617F mutant in human SET2 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetTyrosine-protein kinase JAK2(Mouse)
West China Hospital of Sichuan University

Curated by ChEMBL
LigandPNGBDBM50559284(CHEMBL4753549)
Affinity DataIC50: 41nMAssay Description:Inhibition of JAK2 V617F mutant in mouse BaF3 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetTyrosine-protein kinase JAK1(Human)
West China Hospital of Sichuan University

Curated by ChEMBL
LigandPNGBDBM50559284(CHEMBL4753549)
Affinity DataIC50: 42nMAssay Description:Inhibition of JAK1 (unknown origin) in presence of Mg/ATP mixture by [gamma p33]-ATP based radiometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetTyrosine-protein kinase JAK2(Human)
West China Hospital of Sichuan University

Curated by ChEMBL
LigandPNGBDBM50559284(CHEMBL4753549)
Affinity DataIC50: 3nMAssay Description:Inhibition of JAK2 (unknown origin) in presence of Mg/ATP mixture by [gamma p33]-ATP based radiometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetTyrosine-protein kinase JAK3(Human)
West China Hospital of Sichuan University

Curated by ChEMBL
LigandPNGBDBM50559284(CHEMBL4753549)
Affinity DataIC50: 94nMAssay Description:Inhibition of JAK3 (unknown origin) in presence of Mg/ATP mixture by [gamma p33]-ATP based radiometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetNon-receptor tyrosine-protein kinase TYK2(Human)
West China Hospital of Sichuan University

Curated by ChEMBL
LigandPNGBDBM50559284(CHEMBL4753549)
Affinity DataIC50: 75nMAssay Description:Inhibition of TYK2 (unknown origin) in presence of Mg/ATP mixture by [gamma p33]-ATP based radiometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
West China Hospital of Sichuan University

Curated by ChEMBL
LigandPNGBDBM50559284(CHEMBL4753549)
Affinity DataIC50: 62nMAssay Description:Inhibition of FLT3 (unknown origin) in presence of Mg/ATP mixture by [gamma p33]-ATP based radiometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed