BDBM50559193 CHEMBL4749352

SMILES C[C@@H]1COCCN1c1nc(nc(n1)-c1cnc(N)cc1C(F)F)N1[C@@H](C)COC[C@H]1C

InChI Key InChIKey=YXQKBQLVKBUCLZ-UHFFFAOYSA-N

Data  2 KI  7 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 50559193   

TargetSerine/threonine-protein kinase mTOR(Human)
University of Basel

Curated by ChEMBL
LigandPNGBDBM50559193(CHEMBL4749352)
Affinity DataKd:  0.670nMAssay Description:Binding affinity to wild-type human partial length MTOR (L1382 to W2549 residues) expressed in HEK293 cells measured after 1 hr by Kinomescan methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details Article
PubMed
LigandPNGBDBM50559193(CHEMBL4749352)
Affinity DataKd:  110nMAssay Description:Binding affinity to wild-type human partial length PIK3CA (R108 to N1068 residues) expressed in HEK293 cells measured after 1 hr by Kinomescan methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details Article
PubMed
LigandPNGBDBM50559193(CHEMBL4749352)
Affinity DataKd:  1.45E+3nMAssay Description:Binding affinity to wild-type human partial length PIK3CB (P118 to S1070 residues) expressed in HEK293 cells measured after 1 hr by Kinomescan methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details Article
PubMed
LigandPNGBDBM50559193(CHEMBL4749352)
Affinity DataKd:  3.50E+3nMAssay Description:Binding affinity to wild-type human partial length PIK3CD (R108 to Q1044 residues) expressed in HEK293 cells measured after 1 hr by Kinomescan methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details Article
PubMed
LigandPNGBDBM50559193(CHEMBL4749352)
Affinity DataKd:  1.35E+3nMAssay Description:Binding affinity to wild-type human partial length PIK3CG (S144 to A1102 residues) expressed in HEK293 cells measured after 1 hr by Kinomescan methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details Article
PubMed
TargetPhosphatidylinositol 4-kinase beta(Human)
University of Basel

Curated by ChEMBL
LigandPNGBDBM50559193(CHEMBL4749352)
Affinity DataKd: >3.00E+4nMAssay Description:Binding affinity to wild-type human full length PIK4CB (M1 to M828 residues) expressed in HEK293 cells measured after 1 hr by Kinomescan methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details Article
PubMed
TargetPhosphatidylinositol 3-kinase catalytic subunit type 3(Human)
University of Basel

Curated by ChEMBL
LigandPNGBDBM50559193(CHEMBL4749352)
Affinity DataKd:  65nMAssay Description:Binding affinity to wild-type human partial length VPS34 (S282 to H879 residues) expressed in HEK293 cells measured after 1 hr by Kinomescan methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase mTOR(Human)
University of Basel

Curated by ChEMBL
LigandPNGBDBM50559193(CHEMBL4749352)
Affinity DataKi:  3.60nMAssay Description:Inhibition of alexa fluor 647-labeled kinase tracer 314 binding to recombinant human N-terminal GST-tagged mTOR (1360 to 2549 residues) expressed in ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details Article
PubMed
LigandPNGBDBM50559193(CHEMBL4749352)
Affinity DataKi:  287nMAssay Description:Inhibition of alexa fluor 647-labeled kinase tracer 314 binding to recombinant human N-terminal His-tagged p110alpha/p85alpha expressed in baculoviru...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details Article
PubMed