BDBM50559027 CHEMBL4747318

SMILES C\C(=N\O)c1ccc(NC(=O)CSc2nnc(-c3cc(nc4ccccc34)-c3ccccc3)n2CC=C)cc1

InChI Key InChIKey=KHOUPLYHJRQMOU-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50559027   

TargetSignal transducer and activator of transcription 3(Human)
The University of Texas At Austin

Curated by ChEMBL
LigandPNGBDBM50559027(CHEMBL4747318)
Affinity DataIC50: 320nMAssay Description:Displacement of FAM-labeled 5-GpYLPQTV-NH2 from recombinant GST-tagged STAT3 (unknown origin) preincubated for 30 mins followed by FAM-labeled 5-GpYL...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details Article
PubMed
TargetSignal transducer and activator of transcription 3(Human)
The University of Texas At Austin

Curated by ChEMBL
LigandPNGBDBM50559027(CHEMBL4747318)
Affinity DataIC50: 6.30E+3nMAssay Description:Inhibition of STAT3 in human SB-590885-sensitive 451Lu cells assessed as reduction in STAT3 transcriptional activity measured after 12 hrs by Dual-lu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details Article
PubMed
TargetSignal transducer and activator of transcription 3(Human)
The University of Texas At Austin

Curated by ChEMBL
LigandPNGBDBM50559027(CHEMBL4747318)
Affinity DataIC50: 4.70E+3nMAssay Description:Inhibition of STAT3 in human SB-590885-resistant 451Lu cells assessed as reduction in STAT3 transcriptional activity measured after 12 hrs by Dual-lu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details Article
PubMed
TargetSignal transducer and activator of transcription 3(Human)
The University of Texas At Austin

Curated by ChEMBL
LigandPNGBDBM50559027(CHEMBL4747318)
Affinity DataIC50: 1.03E+4nMAssay Description:Inhibition of STAT3 in human SB-590885-sensitive MEL1617 cells assessed as reduction in STAT3 transcriptional activity measured after 12 hrs by Dual-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details Article
PubMed
TargetSignal transducer and activator of transcription 3(Human)
The University of Texas At Austin

Curated by ChEMBL
LigandPNGBDBM50559027(CHEMBL4747318)
Affinity DataIC50: 9.90E+3nMAssay Description:Inhibition of STAT3 in human SB-590885-resistant MEL1617 cells assessed as reduction in STAT3 transcriptional activity measured after 12 hrs by Dual-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details Article
PubMed