BDBM50558981 CHEMBL4780781

SMILES FC(F)(F)Oc1ccc(OCCCCN2CCn3c(nc4ccccc34)C2=O)cc1

InChI Key InChIKey=QRCUMXUPIXTGPF-UHFFFAOYSA-N

Data  10 IC50  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 12 hits for monomerid = 50558981   

TargetMetabotropic glutamate receptor 2(Human)
Gedeon Richter

Curated by ChEMBL
LigandPNGBDBM50558981(CHEMBL4780781)
Affinity DataEC50:  30nMAssay Description:Positive allosteric modulation of human mGlu2 receptor stably expressed in human Chem-1 cells assessed as potentiation of glutamate-induced intracell...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details Article
PubMed
TargetCytochrome P450 1A2(Human)
Gedeon Richter

Curated by ChEMBL
LigandPNGBDBM50558981(CHEMBL4780781)
Affinity DataIC50: 9.40E+3nMAssay Description:Inhibition of CYP1A2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details Article
PubMed
TargetCytochrome P450 2C9(Human)
Gedeon Richter

Curated by ChEMBL
LigandPNGBDBM50558981(CHEMBL4780781)
Affinity DataIC50: 7.00E+3nMAssay Description:Inhibition of CYP2C9 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details Article
PubMed
TargetCytochrome P450 2C19(Human)
Gedeon Richter

Curated by ChEMBL
LigandPNGBDBM50558981(CHEMBL4780781)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CYP2C19 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details Article
PubMed
TargetCytochrome P450 2D6(Human)
Gedeon Richter

Curated by ChEMBL
LigandPNGBDBM50558981(CHEMBL4780781)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CYP2D6 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Gedeon Richter

Curated by ChEMBL
LigandPNGBDBM50558981(CHEMBL4780781)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CYP3A4 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 2(Human)
Gedeon Richter

Curated by ChEMBL
LigandPNGBDBM50558981(CHEMBL4780781)
Affinity DataEC50:  30nMAssay Description:Positive allosteric modulator activity at human mGlu2 receptor expressed in rat Chem-1 cells assessed as cytosolic Ca2+ ion concentration measured af...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed
TargetCytochrome P450 1A2(Human)
Gedeon Richter

Curated by ChEMBL
LigandPNGBDBM50558981(CHEMBL4780781)
Affinity DataIC50: 9.40E+3nMAssay Description:Inhibition of CYP1A2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed
TargetCytochrome P450 2D6(Human)
Gedeon Richter

Curated by ChEMBL
LigandPNGBDBM50558981(CHEMBL4780781)
Affinity DataIC50: 7.00E+3nMAssay Description:Inhibition of CYP2D6 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed
TargetCytochrome P450 2C9(Human)
Gedeon Richter

Curated by ChEMBL
LigandPNGBDBM50558981(CHEMBL4780781)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CYP2C9 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Gedeon Richter

Curated by ChEMBL
LigandPNGBDBM50558981(CHEMBL4780781)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CYP3A4 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed
TargetNuclear receptor subfamily 1 group I member 2(Human)
Gedeon Richter

Curated by ChEMBL
LigandPNGBDBM50558981(CHEMBL4780781)
Affinity DataIC50: 7.70E+3nMAssay Description:Activation of PXR (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed