BDBM50558881 CHEMBL4761836

SMILES NC[C@H](NC(=O)c1ccc([nH]1)-c1cc(F)c(Cl)c(F)c1)c1nc(CO)cs1

InChI Key InChIKey=BMNRITNXOPKFLG-UHFFFAOYSA-N

Data  9 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 50558881   

TargetCytochrome P450 1A2(Human)
Lindsley F. Kimball Research Institute

Curated by ChEMBL
LigandPNGBDBM50558881(CHEMBL4761836)
Affinity DataIC50: 2.50E+4nMAssay Description:Inhibition of human liver microsome CYP1A2 using phenacetin as substrate incubated for 20 mins by LC-MS/MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details Article
PubMed
TargetCytochrome P450 2B6(Human)
Lindsley F. Kimball Research Institute

Curated by ChEMBL
LigandPNGBDBM50558881(CHEMBL4761836)
Affinity DataIC50: 2.50E+4nMAssay Description:Inhibition of human liver microsome CYP2B6 using bupropion as substrate incubated for 20 mins by LC-MS/MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details Article
PubMed
TargetCytochrome P450 2C8(Human)
Lindsley F. Kimball Research Institute

Curated by ChEMBL
LigandPNGBDBM50558881(CHEMBL4761836)
Affinity DataIC50: 2.50E+4nMAssay Description:Inhibition of human liver microsome CYP2C8 using paclitaxel as substrate incubated for 20 mins by LC-MS/MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details Article
PubMed
TargetCytochrome P450 2C9(Human)
Lindsley F. Kimball Research Institute

Curated by ChEMBL
LigandPNGBDBM50558881(CHEMBL4761836)
Affinity DataIC50: 2.50E+4nMAssay Description:Inhibition of human liver microsome CYP2C9 using diclofenac as substrate incubated for 20 mins by LC-MS/MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details Article
PubMed
TargetCytochrome P450 2C19(Human)
Lindsley F. Kimball Research Institute

Curated by ChEMBL
LigandPNGBDBM50558881(CHEMBL4761836)
Affinity DataIC50: 2.50E+4nMAssay Description:Inhibition of human liver microsome CYP2C19 using mephenytoin as substrate incubated for 20 mins by LC-MS/MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details Article
PubMed
TargetCytochrome P450 2D6(Human)
Lindsley F. Kimball Research Institute

Curated by ChEMBL
LigandPNGBDBM50558881(CHEMBL4761836)
Affinity DataIC50: 2.50E+4nMAssay Description:Inhibition of human liver microsome CYP2D6 using bufuralol as substrate incubated for 20 mins by LC-MS/MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Lindsley F. Kimball Research Institute

Curated by ChEMBL
LigandPNGBDBM50558881(CHEMBL4761836)
Affinity DataIC50: 2.50E+4nMAssay Description:Inhibition of human liver microsome CYP3A4 using testosterone as substrate incubated for 20 mins by LC-MS/MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Lindsley F. Kimball Research Institute

Curated by ChEMBL
LigandPNGBDBM50558881(CHEMBL4761836)
Affinity DataIC50: 2.50E+4nMAssay Description:Inhibition of human liver microsome CYP3A4 using midazolam as substrate incubated for 20 mins by LC-MS/MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Lindsley F. Kimball Research Institute

Curated by ChEMBL
LigandPNGBDBM50558881(CHEMBL4761836)
Affinity DataIC50: 900nMAssay Description:Inhibition of human ERG transfected in HEK293 cells assessed as reduction in channel current at -80 mV holding potential by whole-cell patch clamp me...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details Article
PubMed