BDBM50558874 CHEMBL4794578

SMILES CCOc1nc(Nc2ccc(cc2OC)C(=O)N2CCOCC2)nc2[nH]ccc12

InChI Key InChIKey=OTTOCUYGSZUQOI-UHFFFAOYSA-N

Data  7 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50558874   

TargetLeucine-rich repeat serine/threonine-protein kinase 2(Human)
Gsk Pharmaceuticals R&D

Curated by ChEMBL
LigandPNGBDBM50558874(CHEMBL4794578)
Affinity DataIC50: 13nMAssay Description:Inhibition of recombinant His6-Tev-LRRK2 (1326 to 2527 residues) (unknown origin) using LRRKtide as substrate preincubated for 30 mins followed by su...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details Article
PubMed
TargetLeucine-rich repeat serine/threonine-protein kinase 2(Human)
Gsk Pharmaceuticals R&D

Curated by ChEMBL
LigandPNGBDBM50558874(CHEMBL4794578)
Affinity DataIC50: 158nMAssay Description:Inhibition of recombinant full-length LRRK2 (unknown origin) expressed in SH-SY5Y cells assessed as reduction in Ser935 phosphorylation after 60 mins...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details Article
PubMed
TargetLeucine-rich repeat serine/threonine-protein kinase 2(Human)
Gsk Pharmaceuticals R&D

Curated by ChEMBL
LigandPNGBDBM50558874(CHEMBL4794578)
Affinity DataIC50: 32nMAssay Description:Inhibition of LRRK2 in human AHE cells assessed as reduction in Ser935 phosphorylationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details Article
PubMed
TargetLeucine-rich repeat serine/threonine-protein kinase 2(Human)
Gsk Pharmaceuticals R&D

Curated by ChEMBL
LigandPNGBDBM50558874(CHEMBL4794578)
Affinity DataIC50: 16nMAssay Description:Inhibition of LRRK2 G2019S mutant in human ANK cells assessed as reduction in Ser935 phosphorylationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Gsk Pharmaceuticals R&D

Curated by ChEMBL
LigandPNGBDBM50558874(CHEMBL4794578)
Affinity DataIC50: 1.58E+5nMAssay Description:Inhibition of human CYP3A4More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details Article
PubMed
TargetNuclear receptor subfamily 1 group I member 2(Human)
Gsk Pharmaceuticals R&D

Curated by ChEMBL
LigandPNGBDBM50558874(CHEMBL4794578)
Affinity DataEC50: <5.01E+4nMAssay Description:Inhibition of human PXRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details Article
PubMed
TargetSolute carrier organic anion transporter family member 1B1(Human)
Gsk Pharmaceuticals R&D

Curated by ChEMBL
LigandPNGBDBM50558874(CHEMBL4794578)
Affinity DataIC50: 1.26E+4nMAssay Description:Inhibition of human OATP1B1More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Gsk Pharmaceuticals R&D

Curated by ChEMBL
LigandPNGBDBM50558874(CHEMBL4794578)
Affinity DataIC50: 6.31E+4nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details Article
PubMed