BDBM50558870 CHEMBL4743843

SMILES CCOc1nc(Nc2ccc(cc2OC(C)C)C(=O)N2CCOCC2)nc2[nH]ccc12

InChI Key InChIKey=JNEYRGCOLYRABZ-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50558870   

TargetLeucine-rich repeat serine/threonine-protein kinase 2(Human)
Gsk Pharmaceuticals R&D

Curated by ChEMBL
LigandPNGBDBM50558870(CHEMBL4743843)
Affinity DataIC50: 13nMAssay Description:Inhibition of recombinant His6-Tev-LRRK2 (1326 to 2527 residues) (unknown origin) using LRRKtide as substrate preincubated for 30 mins followed by su...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details Article
PubMed
TargetLeucine-rich repeat serine/threonine-protein kinase 2(Human)
Gsk Pharmaceuticals R&D

Curated by ChEMBL
LigandPNGBDBM50558870(CHEMBL4743843)
Affinity DataIC50: 631nMAssay Description:Inhibition of recombinant full-length LRRK2 (unknown origin) expressed in SH-SY5Y cells assessed as reduction in Ser935 phosphorylation after 60 mins...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details Article
PubMed