BDBM50557868 CHEMBL4741305

SMILES CN(C)[C@@H]1CC[C@@H]([C@@H](C1)NC(C)=O)N1CC[C@H](Nc2ncnc3ccc(cc23)C(F)(F)F)C1=O

InChI Key InChIKey=MTLYFKMTORWDHI-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50557868   

TargetC-C chemokine receptor type 2(Human)
Bristol Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50557868(CHEMBL4741305)
Affinity DataIC50: 3.90nMAssay Description:Displacement of [125I]MCP1 from CCR2 in human PBMC measured after 30 mins by Microscintillation counting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
TargetC-C chemokine receptor type 5(Human)
Bristol Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50557868(CHEMBL4741305)
Affinity DataIC50: 8.06E+3nMAssay Description:Antagonist activity at CCR5 in human HT1080 cell membrane assessed as inhibition of [125I]MIP1beta-binding incubated for 4 to 6 hrs by topcount assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
TargetC-C chemokine receptor type 2(Human)
Bristol Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50557868(CHEMBL4741305)
Affinity DataIC50: 4.5nMAssay Description:Antagonist activity at CCR2 in human THP1 cells assessed as reduction in MCP1-induced chemotaxis measured after 30 mins by calcein-AM dye based fluor...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed