BDBM50557686 CHEMBL4751357

SMILES CCOC(=O)C[C@@H]1C[C@@H](C(C)C)[C@H](CNC(=O)c2cncnc2)C=C1C

InChI Key InChIKey=DCHMEPRMQDZOGD-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50557686   

TargetNAD-dependent protein deacetylase sirtuin-2(Human)
Nagoya City University

Curated by ChEMBL
LigandPNGBDBM50557686(CHEMBL4751357)
Affinity DataIC50: 4.79E+4nMAssay Description:Inhibition of 5-(3-((1r,4r)-4-((5S,8S,11S,14S,17S,20S,29S)-11-((1H-imidazol-4-yl)methyl)-1,33-diamino-5-carbamoyl-17-(4-(4-(4-((4-(dimethylamino)phen...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
TargetNAD-dependent protein deacetylase sirtuin-2(Human)
Nagoya City University

Curated by ChEMBL
LigandPNGBDBM50557686(CHEMBL4751357)
Affinity DataIC50: 4.44E+4nMAssay Description:Inhibition of p53(Myr)-AMC binding to SIRT2 (unknown origin) incubated for 3 hrs in presence of NAD+ followed by trypsin addition and measured at 5 m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
TargetNAD-dependent protein deacetylase sirtuin-2(Human)
Nagoya City University

Curated by ChEMBL
LigandPNGBDBM50557686(CHEMBL4751357)
Affinity DataIC50: 5.09E+3nMAssay Description:Inhibition of SIRT2 deacetylation activity (unknown origin) using FLUOR DE LYS SIRT2 peptide as substrate incubated for 2 hrs in presence of NAD+ mea...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed