BDBM50557601 CHEMBL4791349::US12030872, Example 7.4

SMILES CCn1cc(cn1)-n1ncc2cc(Cl)c(cc12)C1CCN(CC1)C1(C)COC1

InChI Key InChIKey=COWVIHDYFDGXET-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50557601   

TargetLeucine-rich repeat serine/threonine-protein kinase 2(Human)
Smith, Gambrell & Russell

Curated by ChEMBL
LigandPNGBDBM50557601(CHEMBL4791349 | US12030872, Example 7.4)
Affinity DataIC50: 0.800nMAssay Description:Inhibition of recombinant human GST tagged LRRK2 G2019S mutant catalytic domain (970 to 2527 residues) expressed in baculovirus expression system usi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
TargetLeucine-rich repeat serine/threonine-protein kinase 2(Human)
Smith, Gambrell & Russell

Curated by ChEMBL
LigandPNGBDBM50557601(CHEMBL4791349 | US12030872, Example 7.4)
Affinity DataIC50: 0.800nMAssay Description:The LRRK2 kinase activity reported herein as IC50 values was determined with LanthaScreen technology from Life Technologies Corporation (Carlsbad, CA...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/16/2024
Entry Details
Go to US Patent

TargetLeucine-rich repeat serine/threonine-protein kinase 2(Human)
Smith, Gambrell & Russell

Curated by ChEMBL
LigandPNGBDBM50557601(CHEMBL4791349 | US12030872, Example 7.4)
Affinity DataIC50: 88nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed