BDBM50557599 CHEMBL4751395::US11485727, Example 2.10

SMILES FC(F)c1ccc(COc2ccc(NCc3ccc(cc3)N3CCN(CC3)C3COC3)nn2)cn1

InChI Key InChIKey=UIDSFTASNOQJJY-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50557599   

TargetAutotaxin(Human)
Smith, Gambrell & Russell

Curated by ChEMBL
LigandPNGBDBM50557599(CHEMBL4751395 | US11485727, Example 2.10)
Affinity DataIC50: 1.80nMAssay Description:Inhibition of recombinant human C-terminal His6-tagged ATX expressed in baculovirus infected Sf21 insect cells using LPC as substrate incubated for 2...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
TargetAutotaxin(Human)
Smith, Gambrell & Russell

Curated by ChEMBL
LigandPNGBDBM50557599(CHEMBL4751395 | US11485727, Example 2.10)
Affinity DataIC50: 1.80nMAssay Description:5 nM recombinant ATX (Cayman Chemicals) was supplemented to 50 mM Tris buffer (pH 8.0) containing 3 mM KCl, 1 mM CaCl2, 1 mM MgCl2 0.14 mM NaCl, and ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/6/2023
Entry Details
Go to US Patent