BDBM50557567 CHEMBL4789686

SMILES c1cc(oc1CCCCc2cc3c(s2)N=C(NC3=O)N)C(=O)N[C@@H](CCC(=O)O)C(=O)O

InChI Key InChIKey=LYDGQYDYRQVOBF-UHFFFAOYSA-N

Data  1 KI  4 IC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50557567   

TargetReduced folate transporter(Human)
Wayne State University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50557567(CHEMBL4789686)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of human RFC expressed in Chinese Hamster MTXRII-OuaR2-4 R2 cells assessed as reduction in cell proliferation after 96 hrs by CellTiter-bl...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
TargetFolate receptor alpha(Human)
Wayne State University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50557567(CHEMBL4789686)
Affinity DataIC50: 11nMAssay Description:Inhibition of human FRalpha expressed in Chinese Hamster MTXRII-OuaR2-4 R2 cells assessed as reduction in cell proliferation after 96 hrs by CellTite...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
TargetFolate receptor beta(Human)
Wayne State University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50557567(CHEMBL4789686)
Affinity DataIC50: 2.60nMAssay Description:Inhibition of human FRbeta expressed in Chinese Hamster MTXRII-OuaR2-4 R2 cells assessed as reduction in cell proliferation after 96 hrs by CellTiter...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
TargetProton-coupled folate transporter(Human)
Wayne State University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50557567(CHEMBL4789686)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of human PCFT expressed in Chinese Hamster MTXRII-OuaR2-4 R2 cells assessed as reduction in cell proliferation after 96 hrs by CellTiter-b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
TargetBifunctional purine biosynthesis protein ATIC(Human)
Wayne State University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50557567(CHEMBL4789686)
Affinity DataKi:  2.47E+4nMAssay Description:Inhibition of human full length N-terminal His-tagged ATIC expressed in Chinese Hamster MTXRII-OuaR2-4 R2 cells assessed as reduction in THF formatio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed