BDBM50557482 CHEMBL4747591

SMILES Cn1cc(Nc2nccc(n2)N2CC3CCC(C2)N3C(=O)[C@@H]2CC2(F)F)cn1

InChI Key InChIKey=BUWBRTXGQRBBHG-UHFFFAOYSA-N

Data  13 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 13 hits for monomerid = 50557482   

TargetTyrosine-protein kinase JAK1(Human)
Roche Innovation Center Shanghai

Curated by ChEMBL
LigandPNGBDBM50557482(CHEMBL4747591)
Affinity DataIC50: 17nMAssay Description:Inhibition of recombinant human JAK1 assessed as phosphorylation level in presence of 1 mM ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Roche Innovation Center Shanghai

Curated by ChEMBL
LigandPNGBDBM50557482(CHEMBL4747591)
Affinity DataIC50: 77nMAssay Description:Inhibition of recombinant human JAK2 assessed as phosphorylation level in presence of 1 mM ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK3(Human)
Roche Innovation Center Shanghai

Curated by ChEMBL
LigandPNGBDBM50557482(CHEMBL4747591)
Affinity DataIC50: 6.49E+3nMAssay Description:Inhibition of recombinant human JAK3 assessed as phosphorylation level in presence of 1 mM ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
TargetNon-receptor tyrosine-protein kinase TYK2(Human)
Roche Innovation Center Shanghai

Curated by ChEMBL
LigandPNGBDBM50557482(CHEMBL4747591)
Affinity DataIC50: 23nMAssay Description:Inhibition of recombinant human Tyk2 expressed in sf21 baculovirus expression system assessed as phosphorylation level in presence of 1 mM ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Roche Innovation Center Shanghai

Curated by ChEMBL
LigandPNGBDBM50557482(CHEMBL4747591)
Affinity DataIC50: 77nMAssay Description:Inhibition of JAK 2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetTyrosine-protein kinase JAK1(Human)
Roche Innovation Center Shanghai

Curated by ChEMBL
LigandPNGBDBM50557482(CHEMBL4747591)
Affinity DataIC50: 17nMAssay Description:Inhibition of JAK 1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetTyrosine-protein kinase JAK1(Human)
Roche Innovation Center Shanghai

Curated by ChEMBL
LigandPNGBDBM50557482(CHEMBL4747591)
Affinity DataIC50: 11nMAssay Description:Inhibition of JAK1 JH1 domain (unknown origin) using FITC-Ahx-KKSRGDYMTMQIG-NH2 peptide as substrate incubated for 60 mins in the presence of ATP by ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Roche Innovation Center Shanghai

Curated by ChEMBL
LigandPNGBDBM50557482(CHEMBL4747591)
Affinity DataIC50: 26nMAssay Description:Inhibition of JAK2 JH1 domain (unknown origin) using Carboxyfluorescein-Ahx-GGEEEEYFELVKKKK peptide as substrate incubated for 60 mins in the presenc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
TargetTyrosine-protein kinase JAK3(Human)
Roche Innovation Center Shanghai

Curated by ChEMBL
LigandPNGBDBM50557482(CHEMBL4747591)
Affinity DataIC50: 1.54E+3nMAssay Description:Inhibition of JAK3 JH1 domain (unknown origin) using Carboxyfluorescein-Ahx-GGEEEEYFELVKKKK peptide as substrate incubated for 60 mins in the presenc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
TargetNon-receptor tyrosine-protein kinase TYK2(Human)
Roche Innovation Center Shanghai

Curated by ChEMBL
LigandPNGBDBM50557482(CHEMBL4747591)
Affinity DataIC50: 5.20nMAssay Description:Inhibition of TYK2 (unknown origin) by caliper technologyMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
LigandPNGBDBM50557482(CHEMBL4747591)
Affinity DataIC50: 54nMAssay Description:Inhibition of JAK1/JAK3 in human M07E cells assessed as reduction of IL-15 stimulated STAT phosphorylation preincubated for 30 mins followed by IL-15...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
LigandPNGBDBM50557482(CHEMBL4747591)
Affinity DataIC50: 73nMAssay Description:Inhibition of JAK1/TYK2 in human M07E cells assessed as reduction of IFN alpha stimulated STAT phosphorylation preincubated for 30 mins followed by I...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
LigandPNGBDBM50557482(CHEMBL4747591)
Affinity DataIC50: 65nMAssay Description:Inhibition of JAK1/JAK3 in human blood assessed as reduction of IL-2 stimulated STAT phosphorylation preincubated for 30 mins followed by IL-2 stimul...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed