BDBM50557369 CHEMBL4763061

SMILES ONC(=O)c1cnc(nc1)N1CCC2(CCN(Cc3c[nH]c4ccccc34)C2)CC1

InChI Key InChIKey=GTIKSCMYIPBYSS-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50557369   

TargetHistone deacetylase 1(Human)
East China University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50557369(CHEMBL4763061)
Affinity DataIC50: 0.580nMAssay Description:Inhibition of C-terminal His/Flag-tagged human HDAC1 (1 to 482 residues) expressed in Sf9 cells using Ac-peptide as substrate preincubated for 15 min...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
TargetHistone deacetylase 2(Human)
East China University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50557369(CHEMBL4763061)
Affinity DataIC50: 1.80nMAssay Description:Inhibition of human HDAC2 expressed in Sf9 cells using Ac-peptide as substrate preincubated for 15 mins followed by substrate and trypsin addition an...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
TargetHistone deacetylase 3/Nuclear receptor corepressor 2 (HDAC3/NCoR2)(Human)
East China University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50557369(CHEMBL4763061)
Affinity DataIC50: 3nMAssay Description:Inhibition of human C-terminal His-tagged HDAC3/N-terminal GST-tagged NCOR2 expressed in baculovirus infected Sf9 cells using Ac-peptide as substrate...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
TargetHistone deacetylase 8(Human)
East China University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50557369(CHEMBL4763061)
Affinity DataIC50: 16nMAssay Description:Inhibition of full length human C-terminal His-tagged HDAC8 expressed in baculovirus infected Sf9 cells using Ac-peptide as substrate preincubated fo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
TargetHistone deacetylase 6(Human)
East China University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50557369(CHEMBL4763061)
Affinity DataIC50: 32nMAssay Description:Inhibition of human HDAC6 using Ac-peptide as substrate preincubated for 15 mins followed by substrate and trypsin addition and further incubated for...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
TargetNAD-dependent protein deacetylase sirtuin-2(Human)
East China University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50557369(CHEMBL4763061)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human C-terminal His-tagged SIRT2 (50 to 356 residues) expressed in Escherichia coli using Ac-peptide as substrate preincubated for 15 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed