BDBM50557282 CHEMBL4753933

SMILES CC(C)Oc1cc(C2CCN(CCC(=O)NCCOCCNC(=O)C=C)CC2)c(C)cc1Nc1ncc(Cl)c(Nc2ccccc2S(=O)(=O)C(C)C)n1

InChI Key InChIKey=XGZORHKVFKUMAV-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50557282   

TargetALK tyrosine kinase receptor(Human)
West China Hospital of Sichuan University

Curated by ChEMBL
LigandPNGBDBM50557282(CHEMBL4753933)
Affinity DataIC50: 0.5nMAssay Description:Inhibition of N-terminal GST tagged human ALK cytoplasmic domain (1058 to 1620 residues) expressed in Sf21 cells by mobility shift assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
TargetInsulin-like growth factor 1 receptor(Human)
West China Hospital of Sichuan University

Curated by ChEMBL
LigandPNGBDBM50557282(CHEMBL4753933)
Affinity DataIC50: 7.10nMAssay Description:Inhibition of IGF1R (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
TargetInsulin receptor(Human)
West China Hospital of Sichuan University

Curated by ChEMBL
LigandPNGBDBM50557282(CHEMBL4753933)
Affinity DataIC50: 13nMAssay Description:Inhibition of INSR (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
West China Hospital of Sichuan University

Curated by ChEMBL
LigandPNGBDBM50557282(CHEMBL4753933)
Affinity DataIC50: 875nMAssay Description:Inhibition of FLT3 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
TargetFibroblast growth factor receptor 2(Human)
West China Hospital of Sichuan University

Curated by ChEMBL
LigandPNGBDBM50557282(CHEMBL4753933)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of FGFR2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
TargetALK tyrosine kinase receptor(Human)
West China Hospital of Sichuan University

Curated by ChEMBL
LigandPNGBDBM50557282(CHEMBL4753933)
Affinity DataIC50: 1.40nMAssay Description:Covalent inhibition of N-terminal GST tagged human ALK cytoplasmic domain (1058 to 1620 residues) expressed in Sf21 cells incubated for 2 hrs in pres...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed