BDBM50557256 CHEMBL4796010

SMILES COc1cc([S+]([O-])CCN(C)C)c(NC(=O)C=C)cc1Nc1nccc(n1)-c1cn(C2CC2)c2ccccc12

InChI Key InChIKey=MMDVQPKVFJGOII-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50557256   

TargetEpidermal growth factor receptor(Human)
Sun Yat-Sen University

Curated by ChEMBL
LigandPNGBDBM50557256(CHEMBL4796010)
Affinity DataIC50: 0.260nMAssay Description:Inhibition of recombinant human GST-tagged EGFR T790M/L858R double mutant (668 to 1210 residues) expressed in baculovirus expression system using Tyr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Sun Yat-Sen University

Curated by ChEMBL
LigandPNGBDBM50557256(CHEMBL4796010)
Affinity DataIC50: 1.10nMAssay Description:Inhibition of human recombinant GST-tagged EGFR L858R mutant expressed in baculovirus expression system using tyrosine 4 peptide as substrate after 6...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Sun Yat-Sen University

Curated by ChEMBL
LigandPNGBDBM50557256(CHEMBL4796010)
Affinity DataIC50: 4.10nMAssay Description:Inhibition of recombinant human GST-tagged EGFR expressed in baculovirus expression system using tyr-04 peptide as substrate incubated for 60 mins in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed