BDBM50557164 CHEMBL4778870

SMILES CC1CCN(CC1)c1ccnc(NCc2cn(C)cn2)n1

InChI Key InChIKey=PWKAYICUBVNJAZ-UHFFFAOYSA-N

Data  1 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50557164   

TargetProtein O-GlcNAcase(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50557164(CHEMBL4778870)
Affinity DataIC50: 46nMAssay Description:Inhibition of full-length human OGA expressed in Expi293 (HEK293) cells using 4-methylumbelliferyl-N-acetyl-beta-D-glucosaminide dihydrate as fluorog...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
TargetProtein O-GlcNAcase(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50557164(CHEMBL4778870)
Affinity DataEC50:  450nMAssay Description:Inhibition of OGA in human SH-SY5Y cells assessed as increase in O-GIcNAcylated protein levels incubated for 48 hrs by in-cell Western assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed