BDBM50556388 CHEMBL4741978

SMILES CN(CC#C)Cc1ccc(OCCCCCN2CCN(CC2)c2cccc3n(ccc23)S(=O)(=O)c2ccccc2)cc1

InChI Key InChIKey=CUFJQHNVDRIQJL-UHFFFAOYSA-N

Data  5 KI  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50556388   

TargetAmine oxidase [flavin-containing] B(Human)
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM50556388(CHEMBL4741978)
Affinity DataIC50: 154nMAssay Description:Inhibition of recombinant human MAO-B expressed in baculovirus infected BTI insect cells using p-tyramine as substrate preincubated for 30 mins follo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
TargetAmine oxidase [flavin-containing] A(Human)
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM50556388(CHEMBL4741978)
Affinity DataIC50: 1.04E+3nMAssay Description:Inhibition of recombinant human MAO-A expressed in baculovirus infected BTI insect cells using p-tyramine as substrate preincubated for 30 mins follo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 6(Human)
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM50556388(CHEMBL4741978)
Affinity DataIC50: 860nMAssay Description:Inverse agonist activity at recombinant human 5HT6 receptor expressed in NG108-15 cells assessed as inhibition of cAMP production measured after 5 mi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 6(Human)
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM50556388(CHEMBL4741978)
Affinity DataKi:  38nMAssay Description:Displacement of [3H]-LSD from human 5HT6 receptor expressed in HEK293 cells measured after 1 hr by microbeta plate reader methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2A(Human)
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM50556388(CHEMBL4741978)
Affinity DataKi:  420nMAssay Description:Displacement of [3H]-Ketanserin from human 5HT2A receptor expressed in CHOK1 cells incubated at 27 degree C for 1 hr by microbeta plate reader analys...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1A(Human)
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM50556388(CHEMBL4741978)
Affinity DataKi:  684nMAssay Description:Displacement of [3H]8-OH-DPAT from human 5HT1A receptor expressed in HEK293 cells incubated at room temperature for 1 hr by microbeta plate reader an...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Human)
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM50556388(CHEMBL4741978)
Affinity DataKi:  813nMAssay Description:Displacement of [3H]-raclopride from human D2 receptor expressed in HEK293 cells measured after 1 hr by microbeta plate reader analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 7(Human)
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM50556388(CHEMBL4741978)
Affinity DataKi:  8.00E+3nMAssay Description:Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells measured after 1 hr by microbeta plate reader analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed