BDBM50556042 CHEMBL4740455

SMILES CN1C(N)=N[C@@](C)(C[S@]1(=O)=NCC(F)(F)F)c1cc(NC(=O)c2ncc(cc2C)C#N)ccc1F

InChI Key InChIKey=OOHXZINQBNNEIN-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50556042   

TargetBeta-secretase 1(Human)
Endotherm

Curated by ChEMBL
LigandPNGBDBM50556042(CHEMBL4740455)
Affinity DataIC50: 0.990nMAssay Description:Inhibition of BACE1 in HEK293 cells harboring APP assessed as reduction in amyloidbeta 40 level measured after 18 to 20 hrs by AlphaLISA AssayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed