BDBM50556034 CHEMBL4762845

SMILES COc1cc(F)ccc1-c1cc(Nc2cc(C[S@@](C)(=N)=O)ccn2)ncc1F

InChI Key InChIKey=YZCUMZWULWOUMD-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50556034   

TargetCyclin-T1/Cyclin-dependent kinase 9(Human)
Endotherm

Curated by ChEMBL
LigandPNGBDBM50556034(CHEMBL4762845)
Affinity DataIC50: 4nMAssay Description:Inhibition of recombinant full length His-tagged human CDK9/cyclin T1 expressed in baculovirus expression system using biotinylated peptide biotin-Tt...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
LigandPNGBDBM50556034(CHEMBL4762845)
Affinity DataIC50: 2.92E+3nMAssay Description:Inhibition of recombinant GST-tagged human CDK2/GST-tagged cyclin E expressed in sf9 cells using biotinylated peptide biotin-Ttds-YISPLKSPYKISEG as s...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
TargetCyclin-dependent kinase 12(Human)
Peking Union Medical College

Curated by ChEMBL
LigandPNGBDBM50556034(CHEMBL4762845)
Affinity DataIC50: 425nMAssay Description:Inhibition of CDK12/Cyclin K (unknown origin) preincubated for 10 mins followed by substrate and ATP addition measured after 200 mins by ADP-Glo lumi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed