BDBM50555391 CHEMBL4745956

SMILES OCCCc1cnc(Nc2cnc(cn2)C#N)cc1NCC1CCNCC1

InChI Key InChIKey=ARCKEDFLGKMUNT-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50555391   

TargetSerine/threonine-protein kinase Chk1(Human)
Sareum

Curated by ChEMBL
LigandPNGBDBM50555391(CHEMBL4745956)
Affinity DataIC50: 54nMAssay Description:Inhibition of CHK1 (unknown origin) using 5-FAM-KKKVSRSGLYRSPSMPENLNRPR-COOH peptide as substrate incubated for 1 hr in presence of ATP by caliper mi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase Chk1(Human)
Sareum

Curated by ChEMBL
LigandPNGBDBM50555391(CHEMBL4745956)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CHK1 in human HT-29 cells assessed as abrogation of etoposide-induced G2 checkpoint arrest by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed