BDBM50555381 CHEMBL4797888

SMILES COC(=O)c1cnc(Nc2cnc(cn2)C#N)cc1NCCC1CCNCC1

InChI Key InChIKey=KMQKUYZPKPAMNR-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50555381   

TargetSerine/threonine-protein kinase Chk1(Human)
Sareum

Curated by ChEMBL
LigandPNGBDBM50555381(CHEMBL4797888)
Affinity DataIC50: 11nMAssay Description:Inhibition of CHK1 (unknown origin) using 5-FAM-KKKVSRSGLYRSPSMPENLNRPR-COOH peptide as substrate incubated for 1 hr in presence of ATP by caliper mi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase Chk2(Human)
Sareum

Curated by ChEMBL
LigandPNGBDBM50555381(CHEMBL4797888)
Affinity DataIC50: 9.80E+3nMAssay Description:Inhibition of CHK2 (unknown origin) using Biotin-KKKVSRSGLYRSPSMPENLNRPR peptide as substrate incubated for 30 mins in presence of ATP by dissociatio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase Chk1(Human)
Sareum

Curated by ChEMBL
LigandPNGBDBM50555381(CHEMBL4797888)
Affinity DataIC50: 440nMAssay Description:Inhibition of CHK1 in human HT-29 cells assessed as abrogation of etoposide-induced G2 checkpoint arrest by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
TargetCyclin-dependent kinase 1(Human)
Sareum

Curated by ChEMBL
LigandPNGBDBM50555381(CHEMBL4797888)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CDK1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed