BDBM50555147 CHEMBL4748886

SMILES Cc1c(COc2cc(OCc3cccc(c3)C#N)c(CN3CCCCC3C(=O)NCCN)cc2Cl)cccc1-c1ccccc1

InChI Key InChIKey=MUNAGIHEZQSSOB-UHFFFAOYSA-N

Data  1 IC50  4 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50555147   

TargetProgrammed cell death 1 ligand/protein 1(Human)
Southern Medical University

Curated by ChEMBL
LigandPNGBDBM50555147(CHEMBL4748886)
Affinity DataIC50: 9.10nMAssay Description:Inhibition of PD-1/PDL1 (unknown origin) measured after 2 hrs by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2022
Entry Details Article
PubMed
TargetProgrammed cell death 1 ligand 1(Human)
Southern Medical University

Curated by ChEMBL
LigandPNGBDBM50555147(CHEMBL4748886)
Affinity DataKd:  88nMAssay Description:Binding affinity to human PD-L1 by isothermal titration calorimetric analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2022
Entry Details Article
PubMed
TargetProgrammed cell death 1 ligand 1(Mouse)
Southern Medical University

Curated by ChEMBL
LigandPNGBDBM50555147(CHEMBL4748886)
Affinity DataKd:  174nMAssay Description:Binding affinity to mouse PD-L1 by isothermal titration calorimetric analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2022
Entry Details Article
PubMed
TargetProgrammed cell death 1 ligand 1(Human)
Southern Medical University

Curated by ChEMBL
LigandPNGBDBM50555147(CHEMBL4748886)
Affinity DataKd:  202nMAssay Description:Binding affinity to human PD-L1 by surface plasmon resonanceMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2022
Entry Details Article
PubMed
TargetProgrammed cell death 1 ligand 1(Mouse)
Southern Medical University

Curated by ChEMBL
LigandPNGBDBM50555147(CHEMBL4748886)
Affinity DataKd:  47nMAssay Description:Binding affinity to mouse PD-L1 by surface plasmon resonanceMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2022
Entry Details Article
PubMed