BDBM50553980 CHEMBL4751112

SMILES OC(=O)c1cc(F)c2nc(sc2c1)N1CCC(F)(COCc2c(onc2-c2ccccc2C(F)(F)F)C2CC2)CC1

InChI Key InChIKey=VUPXUXWHLJNHNS-UHFFFAOYSA-N

Data  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50553980   

TargetBile acid receptor(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50553980(CHEMBL4751112)
Affinity DataEC50:  3.98E+3nMAssay Description:Agonist activity at GST-tagged human FXR LBD assessed as induction of biotinylated coactivator SRC-1 peptide recruitment measured after 2 hrs by stre...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2022
Entry Details Article
PubMed
TargetBile acid receptor(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50553980(CHEMBL4751112)
Affinity DataEC50:  180nMAssay Description:Agonist activity at human FXR expressed in HEK293 cells measured after 18 hrs by steady-glo luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2022
Entry Details Article
PubMed