BDBM50553961 CHEMBL4800163

SMILES OC(=O)c1csc2cc(ccc12)N1CCC(F)(COCc2c(onc2-c2c(Cl)cccc2Cl)C2CC2)CC1

InChI Key InChIKey=IASAYYMYCTUFNZ-UHFFFAOYSA-N

Data  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50553961   

TargetBile acid receptor(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50553961(CHEMBL4800163)
Affinity DataEC50:  2.89E+3nMAssay Description:Agonist activity at GST-tagged human FXR LBD assessed as induction of biotinylated coactivator SRC-1 peptide recruitment measured after 2 hrs by stre...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2022
Entry Details Article
PubMed
TargetBile acid receptor(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50553961(CHEMBL4800163)
Affinity DataEC50:  96nMAssay Description:Agonist activity at human FXR expressed in HEK293 cells measured after 18 hrs by steady-glo luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2022
Entry Details Article
PubMed