BDBM50553945 CHEMBL4790034

SMILES CCOC(=O)[C@@H](Cc1cnccn1)NC(=O)Nc1c2CCCc2cc2CCCc12

InChI Key InChIKey=JALGAMNPHRBOTO-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50553945   

LigandPNGBDBM50553945(CHEMBL4790034)
Affinity DataIC50: 30nMAssay Description:Inhibition of NLRP3 in human PBMC cells assessed as inhibition of LPS and ATP-induced IL-1beta productionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2022
Entry Details Article
PubMed
LigandPNGBDBM50553945(CHEMBL4790034)
Affinity DataIC50: 370nMAssay Description:Inhibition of NLRP3 in human whole blood assessed as inhibition of LPS and ATP-induced IL-1beta productionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2022
Entry Details Article
PubMed
LigandPNGBDBM50553945(CHEMBL4790034)
Affinity DataIC50: 200nMAssay Description:Inhibition of NLRP3 in human THP-1 cells assessed as reduction in nigercin-induced ASC speck formation measuring green fluorescent protein aggregatio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2022
Entry Details Article
PubMed